hantavirus

Antiviral Research 57 (2003) 121 127HantavirusJan P. Clement Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology,Rega Institute and Leuven University Hospitals, Kapucijnenvoer 33, BE-3000 Leuven, BelgiumReceived 25 September 2002; accepted 8 October 2002AbstractWhen hantaviruses hit the headlines with the advent in May 1993 of a new disease in the USA, and later in the New World from Canadato south Argentina, called hantavirus pulmonary syndrome (HPS), speculations in the lay press rose from the very beginning around thepossibilities of a biological warfare (BW) weapon. Indeed, the responsible agent of HPS, hantavirus, was almost unknown at that momentin the New World, was airborne, seemed to target preferentially young adults, and induced a devastating cardio-pulmonary collapse witha high case-fatality rate (50%), often within hours. It quickly became clear, however, that the same scourge had been known for manyyears in the Old World under different and mostly milder presentations. With the rapidly increasing knowledge about hantaviruses, it alsobecame clear that they lack many of the potentials of an ideal BW weapon, as will be explained in this paper. 2002 Elsevier Science B.V. All rights reserved.Keywords: Hantavirus (HTV); Hantavirus pulmonary syndrome (HPS); Hemorrhagic fever with renal syndrome (HFRS); Nephropathia epidemica (NE);Rodent-borne infection; Biological warfare (BW); Vaccines1. D(有哪些以lia开头的四字成语？没有lia字开头的成语，QQ接龙红包“一个顶俩”难倒了不少网友，根据成语词典提示，成语中含有俩（lia）的成语有：鬼蜮伎俩、鬼魅伎俩、有三有俩、鬼蜮技俩、一个顶俩。可是，按照规定，必须是俩（lia）开头的成语才可以。但是并没有俩（lia）开头的成语，所以这是一个无解的成语接龙呢。)escription of the virusIn contrast to the other viral hemorrhagic fever (VHF)viruses considered as potential agents for biological warfare(BW), hantaviruses (HTVs) are the only VHF viruses witha worldwide distribution, with documented clinical cases onthe Eurasian landmass and the American continent. HTVwas genetically characterized as a new genus in the Bun-yaviridae family (Schmaljohn et al., 1985), where it is theonly nonarthropod-borne pathogen. HTVs possess a tripar-tite, single-stranded, negative sense RNA genome enclosedin circular nucleocapsid structures and...